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Am J Geriatr Psychiatry 16:519-522, June 2008
© 2008 American Association for Geriatric Psychiatry
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Brief Reports

Metabolic Syndrome and Cognitive Decline in Chinese Older Adults: Results From the Singapore Longitudinal Ageing Studies

Roger C.M. Ho, M.B.B.S., D.P.M., M.M.E.D., Mathew Niti, Ph.D., Keng Bee Yap, M.B.B.S., D.G.M. (Lond.), F.R.C.P. (Edin.), Ee Heok Kua, M.D., F.R.C.Psych., and Tze-Pin Ng, M.B.B.S., M.D.

From the Department of Psychological Medicine, National University of Singapore, Singapore (RCMH, MN, EHK, T-PN); Department of Geriatric Medicine, Alexandra Hospital, Singapore (KBY); and Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore (MN, T-PN).

Objective: To determine the association of the metabolic syndrome (MS) with cognitive decline in a Chinese older population.

Methods: In a prospective cohort study of 1,352 community-living Chinese older adults without cognitive impairment (Mini Mental State Examination, MMSE <24) and without cardiovascular disease and stroke, the authors assessed baseline MS (defined according to International Diabetic Federation Criteria). Cognitive decline was predefined as at least 2-point drop in MMSE score at follow-up 1–2 years after baseline assessment.

Results: MS was present in 26.3% of the participants at baseline and was significantly associated with the risk of cognitive decline (odds ratio, 1.42: confidence interval, 1.01–1.98), after controlling for potential confounding by age, gender, education, smoking, alcohol drinking, depressive symptoms, APOE-e4 status, level of leisure activities, baseline MMSE, and length of follow-up.

Conclusion: The MS was associated with increased risk of cognitive decline in Chinese older adults.

Key Words: Metabolic syndrome • cognitive decline • Chinese older adults






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